Integrated strategy for preventing delayed renal graft function

Objective: to determine the efficacy and safety of an integrated strategy aimed at preventing delayed renal graft function (DGF). Materials methods . From June 2018 December 2022, 478 deceased-donor kidney transplants were performed Botkin Hospital, Moscow. The patients divided into two groups: Group I consisted 128 who did not use strategy; II included 67 in whom DGF prevention was used perioperative stage. involved hypothermic oxygenated machine perfusion (HOPE) using expanded criteria donors, a second warm ischemia (SWI) elimination device, personalized initial calcineurin inhibitor (CI) dosing, alprostadil for high vascular resistance arteries. Results. occurred 5 44 (11.4%) that strategy, 13 (29.5%) control group. differences statistically significant (p = 0.034), there medium strength relationship between traits (V 0.225). approach reduced chances developing by factor 0.3 (95% CI: 0.1–0.95). risk group 61.3% non-strategy group, thus relative (RR) is 1.63 1.1–2.4). Median duration normalization significantly lower II: (IQR: 3–9) versus 15 7–19) days 0.012). Mean length hospital stay 19.1 ± 4.2 14.5–26.1) bed-days 13.9 3.4 9.3–17.2) II. Differences this indicator also 0.043). Conclusion. set measures, developed evidence-based implemented clinical practice, can reduce burden modifiable factors complication significantly, thereby improving treatment outcomes transplant recipients considerably.